Junho K. Hur

FX-seq improves snRNA-seq from FFPE and PFA-fixed tissues by removing crosslinks and preventing RNA leakage, enabling analysis of 321,710 nuclei from mouse and human samples.

shRNAI is a deep learning model that designs potent shRNAmir gRNAs by incorporating sequence and contextual features, outperforming existing methods on both simulated and experimental data.

The paper was withdrawn due to significant content changes, and the authors do not wish it to be cited.

The paper develops a method to detect CRISPR off-target mutations with high sensitivity using predicted off-target-specific amplification, showing significantly improved detection rates compared to existing methods.