Genetic architecture of brain age and its casual relations with brain and mental disorders
Esten Høyland Leonardsen, Dídac Vidal-piñeiro A, James M. Roe…·Yunpeng Wang
The paper estimates brain age gap (BAG) using neural networks and identifies eight genomic regions associated with BAG, finding causal relationships with Alzheimer's and bipolar disorder but not Parkinson's, depression, or schizophrenia.