James M. Roe

Cortical thickness changes precede high levels of amyloid by at least seven years

The paper shows cortical thickness changes occur years before high amyloid levels in Alzheimer's disease, challenging the view that amyloid is the first imaging marker.

Vulnerability to memory decline in aging. A mega-analysis of structural brain change.

This study investigates the relationship between brain atrophy and memory decline in aging using longitudinal data, finding a nonlinear association that intensifies with age and is influenced by APOE ε4 carriership.

Network Segregation During Episodic Memory Shows Age-Invariant Relations with Memory Performance From 7 to 82 Years

The paper examines how brain network segregation relates to episodic memory performance across age, finding age-invariant associations between functional connectivity and memory.

Left-Right Brain-Wide Asymmetry of Neuroanatomy in the Mouse Brain

The paper identifies a brain-wide twisting asymmetry in mice, similar to human cerebral petalia, using data from 3,500 animals across six cohorts.

Reliability of structural brain change in cognitively healthy adult samples.

This study assesses the reliability of structural brain change in cognitively healthy adults over time, finding that longer follow-up periods significantly improve reliability compared to increasing observation frequency.

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers

The paper identifies subtypes of brain structural changes in aging and links them to cognitive decline and Alzheimer's disease biomarkers using MRI data.

Opioid use disorder and brain health: observational andgenetic associations

This paper investigates the causal impact of opioid use disorder on brain health outcomes using observational and genetic analyses, finding increased dementia risk associated with both OUD diagnoses and genetic predisposition to OUD.

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer's disease and uncovers adult lifespan memory decline

The paper shows that higher genetic risk for Alzheimer's disease is linked to faster brain volume loss and memory decline in healthy adults.

Tracing the development and lifespan change of population-level structural asymmetry in the cerebral cortex

The paper analyzes cortical asymmetry across age and datasets, finding stable areal asymmetry and developmental changes in thickness asymmetry, with genetic and phenotypic associations.

Genetic architecture of brain age and its casual relations with brain and mental disorders

The paper estimates brain age gap (BAG) using neural networks and identifies eight genomic regions associated with BAG, finding causal relationships with Alzheimer's and bipolar disorder but not Parkinson's, depression, or schizophrenia.

Left-handedness and its genetic influences are associated with structural asymmetries mapped across the cerebral cortex in 31,864 individuals

The paper associates left-handedness with structural brain asymmetries in specific cortical regions using data from 31,864 individuals and identifies genetic links to these asymmetries.

Individual variations in Brain age relate to early life factors more than to longitudinal brain change

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's Disease

The paper identifies asymmetric thinning of the cerebral cortex across aging and Alzheimer's Disease, showing that the initially thicker hemisphere thins faster, with this pattern replicated across multiple cohorts.

The functional foundations of episodic memory remain stable throughout the lifespan

This study investigates whether the functional foundations of episodic memory encoding remain consistent across the lifespan, finding continuity rather than late-life specificity.

Self-reported sleep problems are related to cortical thinning in aging but not memory decline and amyloid-β accumulation - results from the Lifebrain consortium

The paper examines the relationship between self-reported sleep parameters and cortical thinning in aging, finding associations with specific brain regions but not with memory decline or amyloid-β accumulation.

Age-differences in functional asymmetry during memory retrieval revisited: no evidence for contralateral over-activation or compensation

The paper examines age-related differences in brain asymmetry during memory retrieval using fMRI and finds no evidence for compensatory contralateral over-activation in older adults.