Richard W. Pickersgill

This study uses cryo-EM to determine the structure of the CobST cobaltochelatase motor and reveals how ATP and CobT regulate its assembly and activation for cobalt chelation.

This paper introduces a deep learning method to segment protein binding sites into fragment-specific regions using molecular dynamics data, achieving high accuracy in predicting ligand-binding conformations.

The paper uses AlphaFold and cryo-EM to reveal the structure of the type II secretion system's pilus assembly platform and its organization across membranes.

The paper identifies B12-binding function in multiple DUF4465 proteins across diverse bacterial species.

This study identifies novel cobalamin-binding proteins in Bacteroides thetaiotaomicron and shows their role in extracellular vesicle-mediated nutrient acquisition.

This study analyzes the structure of the native human Prion Protein and compares it with the toxic form causing Sporadic Fatal Insomnia, finding increased flexibility in the mutant form.