Hui Zhang

Modulating Sleep Oscillations Through Targeted Memory Reactivation: Linking Functional Dynamics to Brain Microstructure

This study examines how targeted memory reactivation during sleep affects sleep oscillations, brain microstructure, and motor memory consolidation in healthy adults.

Architecture of the type II secretion system

The paper uses AlphaFold and cryo-EM to reveal the structure of the type II secretion system's pilus assembly platform and its organization across membranes.

Understanding the LLM-based gene embeddings

This study evaluates LLM-derived gene embeddings for pathway information recovery using GSEA, showing they encode substantial biological knowledge.

Development of a Porcine Cell Line Stably Expressing Ephrin-B2 for Nipah Virus Research and Diagnostic Testing

This study develops a pig-derived cell line expressing ephrin-B2, enhancing NiV pseudovirus infectivity and suitability for diagnostic testing and vaccine development.

Excitatory neurons as the default fate in bifurcation of excitatory and inhibitory neuron lineages

The paper identifies a conserved genetic program where excitatory neuron fate is the default in EX-IN lineages, with Notch signaling enabling inhibitory fate.

Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue

This study examines how exercise training affects subcutaneous white adipose tissue transcriptomes in individuals with obesity and T2D, finding that exercise reverses detrimental gene expression patterns and correlates with improved metabolic markers.

A proximity-dependent biotinylation map of a human cell: an interactive web resource

Profiling 192 subcellular markers by proximity-dependent biotinylation (BioID) in human HEK 293 cells maps 4,145 proteins across 32 compartments via 35,902 interactions, available with analysis tools at humancellmap.org.

Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human

This study identifies CalDAG-GEFI mutations causing psychomotor symptoms and bleeding in multiple species, revealing conserved signaling deficits in striatal function.

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

This study evaluates SWATH-MS across 11 labs, showing consistent detection and quantification of over 4,000 proteins with reproducible quantitative data.

Characteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution

The paper introduces CISD and CISD_loop methods to predict chromatin interactions from MNase-seq and Hi-C data, achieving kilobase resolution with low data requirements.

Mutation rate estimation for 15 autosomal STR loci in a large population from Mainland China

This study estimates mutation rates for 15 autosomal STR loci in a large Chinese population and finds higher paternal mutation rates and correlations with age and geographic location.