Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum
Rachel L. Mintz, Jichang Han, Emily G. Butka, Alexandre Gallerand, Ayoung Kim, Sarah Ning, Nicole K.H. Yiew, Mary Wohltmann, Wei Zou, Nan Zhang, Samantha A. Morris, Bernd H. Zinselmeyer, Gwendalyn J. Randolph
This study shows that adipocytes are not essential for ovarian cancer growth in the omentum, but endothelial FABP4 plays a critical role in supporting tumor metabolic growth.
bioRxiv · Oct 28, 2025 · PreprintCancer Biology