Rachel L. Mintz

Adipocyte Expression of O-Glycoprotein Procollagen C-Endopeptidase Enhancer Protein 2 (PCPE2): Mechanisms Linking Fibrosis and Beiging of White Adipose Tissue

This study shows that Pcpe2 in adipose tissue contributes to inflammation and fibrosis in obesity and that its absence reduces these effects and enhances adipocyte differentiation.

Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum

This study shows that adipocytes are not essential for ovarian cancer growth in the omentum, but endothelial FABP4 plays a critical role in supporting tumor metabolic growth.

Tracing LYVE1+ peritoneal fluid macrophages unveils two paths to resident macrophage repopulation with differing reliance on monocytes

The paper identifies two distinct pathways for replenishing resident peritoneal macrophages after injury, with differing reliance on monocytes and intermediate stages.

Starfysh reveals heterogeneous spatial dynamics in the breast tumor microenvironment

Starfysh integrates spatial transcriptomics and histology to analyze tumor microenvironments, identifying disease-specific spatial hubs and immune interactions in breast cancers.