Gwendalyn J. Randolph

This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.

This study shows that Pcpe2 in adipose tissue contributes to inflammation and fibrosis in obesity and that its absence reduces these effects and enhances adipocyte differentiation.

This study shows that CSF1R regulates monocyte differentiation and metabolism, with its blockade reducing Ly6Clow monocytes and affecting subset diversity through the hexosamine biosynthetic pathway.

This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

This study identifies GPR182 as a lipoprotein receptor that mediates dietary fat absorption and shows its role in obesity resistance.

This study shows that adipocytes are not essential for ovarian cancer growth in the omentum, but endothelial FABP4 plays a critical role in supporting tumor metabolic growth.

The paper identifies two distinct pathways for replenishing resident peritoneal macrophages after injury, with differing reliance on monocytes and intermediate stages.

This study shows that S1PR1 regulates lymphatic valve development and prevents tertiary lymphoid organ formation in the terminal ileum, suggesting TLOs as a sign of subclinical inflammation.