Author

D. Brent Polk

University of Southern CaliforniaORCID 0000-0001-6680-1554Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Cambrian Y. LiuiD· 3 shared Nandini Girish· 3 shared Safina GadeockiD· 2 shared Tracy C. Grikscheit· 2 shared Ying HuangiD· 2 shared Barun DasiD· 1 shared Benjamin D. SimonsiD· 1 shared Marie L. Gomez· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

Cambrian Y. LiuORCID

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3 papers

Recent·Most cited

Cell BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedJan 1, 2026

TNF Receptor 1 regulates colonic mesenchymal cell diversity and the epithelial stem cell niche.

Safina Gadeock, Nandini Girish, Cambrian Y. Liu…·D. Brent Polk

This study shows TNFR1 promotes colonic mesenchymal cell diversity and stem cell niche function, with TNFR1 deficiency reducing cell diversity and impairing stem cell maintenance.

DOI 10.1016/j.jcmgh.2026.101856

mousescRNA-seq

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Cell BiologybioRxivPreprintSep 8, 2025

TNF signaling drives expansion of Reg4+ epithelial cells in colitis.

Safina Gadeock, Nandini Girish, Cambrian Y. Liu…·D. Brent Polk

This study shows TNF-TNFR1 signaling regulates Reg4+ epithelial cells in colitis, with TNFR1 deficiency reducing them and TNF restoring them, and identifies REG4+ cells as markers of non-responders to anti-TNF therapy.

2 citations

mousehuman

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Developmental BiologybioRxivPreprintJun 2, 2021

Anal skin-like epithelium mediates colonic wound healing

Cambrian Y. Liu, Nandini Girish, Marie L. Gomez…·D. Brent Polk

The paper identifies skin-like epithelial cells that contribute to colonic wound healing in mouse models of colitis.

DOI 10.1101/2021.06.02.446836

mousescRNA-seq

𝕏 PostBluesky