Author

Melissa R. Thomas

Amgen (United States)ORCID 0000-0001-6719-9307Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CITE-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Andrea L. BredemeyeriD· 2 shared Chi-Ming LiiD· 2 shared Junedh AmruteiD· 2 shared Kory J. LavineiD· 2 shared Simon Jackson· 2 shared Steven Hoseong YangiD· 2 shared Tracy YamawakiiD· 2 shared Alekhya ParvathaneniiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersImmunology

Andrea L. BredemeyerORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintSep 21, 2026

Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis

Steven Hoseong Yang, Alekhya Parvathaneni, Yun-Ling Pai…·Kory J. Lavine

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

DOI 10.64898/2026.09.15.751626

mouseexperimental assay

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GenomicsSciencePeer-reviewedJan 29, 2026

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Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

Junedh Amrute, In‐Hyuk Jung, Tracy Yamawaki…·Kory J. Lavine

Single-cell and spatial maps of human coronary arteries identify FAP as a marker of SMC-derived modulated cells; an anti-FAP BiTE reduced plaque burden in mouse models.

37 citationstop 1%

humanmouse

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