Alekhya Parvathaneni

Collateral Immune Cell Signaling Compromises the Efficacy of T-cell Engaging Therapies for Cardiac Fibrosis

This study shows that FAP-targeted BiTE(R) molecules, intended to reduce cardiac fibrosis, instead worsen heart function by triggering harmful immune responses.

Interleukin-1β Drives Disease Progression in Arrhythmogenic Cardiomyopathy

Human arrhythmogenic cardiomyopathy hearts harbor a lesion niche of POSTN fibroblasts and NLRP3+ inflammatory macrophages; IL-1β neutralization in Dsg2-mutant mice reduced fibrosis, dysfunction, and ventricular ectopy.

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

Neuronal Activity Alters Neuron to OPC Synapses

This study shows that neuronal activity influences OPC activation, synapse formation onto OPCs, and the balance of excitatory and inhibitory synapses.