Priyan Bhattacharya

This study develops a computational model of the HNSCC tumor microenvironment to identify subtype-specific resistance mechanisms and predict therapeutic targets for immunotherapy.

This paper develops a systems-theoretic formalism to analyze tumor microenvironment (TME) dynamics and predict immune checkpoint inhibitor (ICI) response by identifying attractor transitions and subtype-specific therapies.

This paper identifies design principles for perfect adaptation in biological networks using nonlinear systems theory, showing that only two network architectures can achieve local adaptation across the state space.

This paper develops a systems-theoretic framework to identify robust adaptation mechanisms in biological networks under deterministic and stochastic conditions.

This paper develops a systems-theoretic method to design adaptive protein networks and shows that third-order networks with negative feedback or feed-forward motifs are necessary for adaptation.