Author

Adam Luginbuhl

Thomas Jefferson UniversityORCID 0000-0001-7682-3108Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Larry A. HarshyneiD· 3 shared Alban J. LinnenbachiD· 2 shared Andrew P. SouthiD· 2 shared Joseph CurryiD· 2 shared M. G. MahoneyiD· 2 shared Adam ErteliD· 1 shared Adam Eugene SnookiD· 1 shared Alice P. PentlandiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersBioengineering

Larry A. HarshyneORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintMay 3, 2026

Translational Opportunity of Engineered IFNγ-eEVs Through Targeted Inhibition of JAK/STAT1 Signaling, Mimicking IVIg Therapy

Kylie E Preihs, Kübra Karagoz, Claire R Shuey…·My G Mahoney

This paper identifies EV-associated cytokines as mediators of IVIg activity, showing that engineered IFNγ-eEVs can suppress IFNγ signaling through context-dependent mechanisms.

DOI 10.64898/2026.04.29.721601

humanproteomics

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Cancer BiologyPLoS Computational BiologyPeer-reviewedJun 3, 2025

Tumor microenvironment governs the prognostic landscape of immunotherapy for head and neck squamous cell carcinoma: A computational model-guided analysis

Priyan Bhattacharya, Alban J. Linnenbach, Andrew P. South…·Rajanikanth Vadigepalli

This study develops a computational model of the HNSCC tumor microenvironment to identify subtype-specific resistance mechanisms and predict therapeutic targets for immunotherapy.

5 citations

humanmultiome

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GenomicsbioRxivPreprintMar 30, 2021

Multimodal genomic markers predict immunotherapy response in the head and neck squamous cell carcinoma

Gaurav Kumar, Andrew P. South, Joseph Curry…·Adam Luginbuhl

The paper evaluates existing ICB biomarkers and identifies a novel signature to predict immunotherapy response in HNSCC using TCGA and clinical trial data.

2 citations

humanwhole-exome sequencing

𝕏 PostBluesky