Keith R. Yamamoto

The paper characterizes the binding and functional landscape of NHR-25, a nuclear hormone receptor in C. elegans, revealing two binding modes and the role of a single response element in regulating gene expression.

The paper uses a genetic screen in C. elegans to identify components of a nuclear receptor transcriptional regulatory complex, revealing a novel co-regulator and its role in modulating gene expression.

The paper defines alleles and altered regulatory motifs in Cas9-edited cell populations using barcode primers and three Python scripts for analysis.

The paper shows that the glucocorticoid receptor ligand-binding domain can control protein activity in C. elegans using a heterologous gene expression system.