BiochemistrybioRxivPreprint
Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase
Marco A. Catipovic, Rachel Green
This study shows that substrate binding, not tRNA or ribosome interactions, activates GCN2 kinase by relieving autoinhibition and promoting autophosphorylation.
DOI 10.64898/2026.09.09.750423