Klaus Brehm

This study investigates the Hippo signaling pathway in Echinococcus multilocularis, showing that inhibiting Hippo signaling disrupts germinative cell-cycle progression and larval development.

This study shows that albendazole targets Echinococcus multilocularis metacestode tissue but spares regenerative stem cells that can regenerate the parasite after drug withdrawal.

This study identifies a conserved core of tegumental proteins in three cestode species through comparative proteomics, revealing shared proteins with trematodes and functional specialization within the tegument.

This study creates a single-cell transcriptomic atlas of Echinococcus multilocularis metacestodes, identifying 26 cell populations and revealing molecular specialization and heterogeneity.

This study shows that canonical WNT signaling is essential for Echinococcus metacestode development, with its disruption causing anteriorization and loss of posterior structures.

The paper identifies EmNRG and EmER1 as a ligand-receptor pair critical for Echinococcus multilocularis stem cell division and metacestode development.

The paper characterizes EmDyp, a Dyp-type peroxidase from Echinococcus multilocularis, showing its enzymatic activity and expression patterns, suggesting a role in ROS defense and potential as a therapeutic target.