Uriel Koziol

Persistence of regenerative stem cells provides a cellular basis for the parasitostatic activity of albendazole against Echinococcus multilocularis

This study shows that albendazole targets Echinococcus multilocularis metacestode tissue but spares regenerative stem cells that can regenerate the parasite after drug withdrawal.

Comparative proteomics reveals a conserved core of tegumental proteins in parasitic flatworms.

This study identifies a conserved core of tegumental proteins in three cestode species through comparative proteomics, revealing shared proteins with trematodes and functional specialization within the tegument.

Coordinated development of the male and female reproductive systems in the cestode Hymenolepis microstoma

The paper characterizes reproductive development in Hymenolepis microstoma, showing coordinated male and female gametogenesis and insemination in vitro.

Canonical WNT signalling governs Echinococcus metacestode development

This study shows that canonical WNT signaling is essential for Echinococcus metacestode development, with its disruption causing anteriorization and loss of posterior structures.

Albendazole specifically disrupts microtubules and protein turnover in the tegument of the cestode Mesocestoides corti

This study shows albendazole disrupts microtubules and reduces protein turnover in the tegument of Mesocestoides corti, suggesting translational inhibition contributes to its anthelmintic effect.

Evolutionary analysis of genome-specific duplications in flatworm genomes

This study analyzes genome-specific duplications in flatworms, finding overrepresented functional categories and conserved expression patterns among inparalogs, supporting gene duplication's role in their evolution.

Stem cell proliferation and differentiation during larval metamorphosis of the model tapeworm Hymenolepis microstoma

This study examines stem cell proliferation and differentiation during larval metamorphosis in Hymenolepis microstoma, identifying rapid tissue formation and lineage-specific gene expression.

Segmentation in tapeworms as a modified form of flatworm posterior regeneration involving Wnt and Hedgehog signalling

The paper investigates Wnt and Hedgehog signaling in tapeworm segmentation, finding that segments form through secondary AP axes linked to neuromuscular systems and regeneration mechanisms.

Insights into in vivo adipocyte differentiation through cell-specific labeling in zebrafish

The paper uses a zebrafish model with a cell-specific adipocyte label to study in vivo adipocyte differentiation, revealing interactions with blood vessels and early lipid metabolic changes.