Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line
Ramya Singh, Ryan B. Smit, Xin Wang, Chris Wang, Hilary Racher, Dave Hansen
The paper shows that reducing Derlin activity suppresses Notch-dependent over-proliferation in C. elegans germline, suggesting a role for ER stress and the UPR in mitigating Notch gain-of-function effects.
PLoS Genetics · Sep 23, 2021Peer-reviewedGenetics