Lihua Ye

This study identifies a Trpa1+EEC-vagal pathway that senses gut pathogens, enhancing host defense and bacterial clearance through coordinated immune and metabolic responses.

This study shows gut microbiota enhances enteroendocrine cell mitochondrial function and maturation through calcium signaling changes.

This study shows high fat diet causes EEC silencing, a nutrient-insensitive state linked to ER stress, which is microbiota-dependent in zebrafish.