Françoise Helmbacher

This study shows that Fat1 deletion increases fibro-adipogenic differentiation and adipogenic expansion in injured skeletal muscle, while having minimal impact on myogenic repair.

The paper identifies a regulatory element in the FAT1 gene deleted in muscular dystrophy patients and shows it drives expression in muscle and mesenchymal cells in transgenic mice.

This study shows that Fat1 regulates astrocyte maturation and angiogenesis in the retina by controlling astrocyte progenitor migration and coupling with endothelial cells.

This study shows Fat1 cadherin has distinct roles in muscle progenitors, mesenchymal cells, and motor neurons to coordinate neuromuscular morphogenesis during development.