Nathalie Caruso

Intrinsically disordered regions influence protein motif usage in Drosophila Ubx and AbdA Hox proteins

The paper shows that intrinsically disordered regions in Drosophila Hox proteins affect the usage of conserved motifs near the homeodomain through context-dependent intramolecular interactions.

RIPOR2 promotes multinucleation of melanoma cells downstream of the RAS/ERK oncogenic pathway

This study identifies RIPOR2 as a downstream target of the RAS/ERK pathway that promotes multinucleation in melanoma cells, contributing to aneuploidy and tumor progression.

An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development

The paper identifies a regulatory element in the FAT1 gene deleted in muscular dystrophy patients and shows it drives expression in muscle and mesenchymal cells in transgenic mice.

Sustained experimental activation of FGF8/ERK in the developing chicken spinal cord reproducibly models early events in ERK-mediated tumorigenesis

The paper shows sustained ERK1/2 activation in chicken embryos induces neoplasia in the spinal cord, mimicking early ERK-mediated tumorigenesis.