Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells
Robert N. Rainey, Sam D Houman, Louise Menendez, Ryan Chang, Litao Tao, Helena Bugacov, Andrew P. McMahon, Radha Kalluri, John S. Oghalai, Andrew K. Groves, Neil Segil
This study develops a virus-free, inducible system to generate human inner ear hair cell-like cells from iPS cells, achieving higher efficiency and faster conversion than viral methods.
bioRxiv · Feb 20, 2025 · PreprintDevelopmental Biology