Helena Bugacov

Inducible, virus-free direct lineage reprogramming enhances scalable generation of human inner ear hair cell-like cells

This study develops a virus-free, inducible system to generate human inner ear hair cell-like cells from iPS cells, achieving higher efficiency and faster conversion than viral methods.

Cadherin Adhesion Complexes Direct Cell Aggregation in the Epithelial Transition of Wnt-Induced Nephron Progenitor Cells

This study shows that Wnt-{beta}-catenin pathway activates cadherin-mediated cell adhesion, driving cell aggregation during the mesenchymal-to-epithelial transition of nephron progenitor cells.

Canonical Wnt transcriptional complexes are essential for induction of nephrogenesis but not maintenance or proliferation of nephron progenitors

The paper investigates the role of canonical Wnt transcriptional complexes in nephron progenitor cell regulation, finding distinct roles in induction versus maintenance of nephrogenesis.

The developing mouse coronal suture at single-cell resolution

This study maps the cellular diversity of the embryonic mouse coronal suture using single-cell transcriptomics, identifying key markers and cell types involved in suture development and fusion.

A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

The paper shows that β-catenin modulates TCF/LEF binding at gene targets, switching from inhibitory to activating complexes during nephron progenitor cell differentiation.