Hilary H Coon

Digging deeper into GWAS signal using GRIN implicates additional genes contributing to suicidal behavior

This study relaxes GWAS significance thresholds and uses GRIN to identify additional genes linked to suicidal behavior, which replicate across cohorts and show stronger biological connections.

Exploring the genetic overlap of suicide-related behaviors and substance use disorders

The paper examines genetic overlaps between suicide-related behaviors and substance use disorders using GWAS summary statistics and finds significant genetic correlations but little evidence of causation.

Rare protein coding variants implicate genes involved in risk of suicide death

The paper identifies five rare SNPs associated with suicide death using genetic data from the USGRS and controls, highlighting their potential role in suicide risk and related biological processes.

Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction

The paper identifies mutation-specific pathophysiological mechanisms in SATB1 variants causing distinct neurodevelopmental disorders.

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

This paper conducts a genome-wide association study of suicide death and shows polygenic scores predict suicide case-control status and related psychiatric traits.

DiI-mediated analysis of pre- and postsynaptic structures in human postmortem brain tissue

This paper introduces a method to analyze synapse-level neuron morphology in human postmortem tissue, finding age-related changes in presynaptic structures but not postsynaptic ones.

Large-scale exome sequencing study implicates both developmental and functional changes in the neurobiology of autism

This study identifies 99 genes associated with autism spectrum disorder through large-scale exome sequencing, showing differences in mutation frequencies between ASD and severe neurodevelopmental delay groups.

Genomewide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide

The paper identifies 207 genes associated with completed suicide using genomic data from 43 high-risk Utah families, finding four significant variants linked to suicide risk.

Lineage: Visualizing Multivariate Clinical Data in Genealogy Graphs

Lineage is a visual analysis tool that maps multifactorial disease analysis to multivariate graph visualization using genealogical, clinical, and genetic data.

Novel pedigree analysis implicates DNA repair and chromatin remodeling in Multiple Myeloma risk

This paper introduces a new pedigree analysis method to identify risk variants for complex diseases, applying it to Multiple Myeloma and finding two genes associated with DNA repair and chromatin remodeling.

High-risk Autism Spectrum Disorder Utah pedigrees: a novel Shared Genomic Segments analysis.

The paper uses a new pedigree analysis method to identify shared genomic segments in high-risk ASD families, finding one genome-wide significant segment and several suggestive regions.