Author

Marlène Pasquet

Centre National de la Recherche ScientifiqueORCID 0000-0001-6919-8383Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bastien GerbyiD· 2 shared Christine DidieriD· 2 shared Cyril BroccardoiD· 2 shared Éric DelabesseiD· 2 shared Laëtitia LargeaudiD· 2 shared Mathieu BouttieriD· 2 shared Naïs PradeiD· 2 shared Sylvie HébrardiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Bastien GerbyORCID

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3 papers

Recent·Most cited

GeneticsThe Journal of Experimental MedicinePeer-reviewedJul 9, 2026

✦ In-depth digest

Humans homozygous for rare or common hypomorphic IL23R variants are prone to tuberculosis

Diana Olguín-Calderón, Laura E. Kilpatrick, Clément Conil…·Stéphanie Boisson‐Dupuis

Homozygosity for hypomorphic IL23R variants (G149R, G300V, R381Q) partly impairs IL-23-dependent IFN-γ production in patient cells; with L372F (effect inferred), they are enriched in tuberculosis, not MSMD or CMC patients.

1 citation

humanwhole-exome sequencing

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Cell BiologybioRxivPreprintJul 3, 2026

USP7 maintains hematopoietic stem cell dormancy and function by stabilizing HMGA2

Antoine Nouhaud, Diaz Anna, Mathieu Bouttier…·Christine Didier

This study identifies USP7 as a regulator of hematopoietic stem cell dormancy by stabilizing HMGA2, showing its role in maintaining stem cell function and longevity.

DOI 10.64898/2026.07.03.731117

mousescRNA-seq

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Cancer BiologybioRxivPreprintDec 18, 2025

Targeting glucocorticoid-induced CD20 activation in preclinical models of B-ALL

Jérémy Bigot, Mathieu Bouttier, Vincent Fregona…·Bastien Gerby

This study identifies CD20 as an actionable target in B-ALL MRD using PDX models and single-cell RNA sequencing, showing anti-CD20 antibodies can eradicate drug-resistant cells.

DOI 10.64898/2025.12.16.694550

humanscRNA-seq

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