Author

Ayaka Sakamoto

Kyoto UniversityORCID 0000-0001-6922-1280Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

Akatsuki SaitoiD· 2 shared Alfredo A. HinayiD· 2 shared Arnon PlianchaisukiD· 2 shared Chihiro MotozonoiD· 2 shared Hayato ItoiD· 2 shared Hirofumi SawaiD· 2 shared Hiroki Futatsusako· 2 shared Hisano YajimaiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Akatsuki SaitoORCID

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2 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedDec 14, 2025

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi…·Miki Kawano

This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.

4 citations

humanexperimental assay

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MicrobiologyNature CommunicationsPeer-reviewedMay 13, 2025

A Protein Language Model for Exploring Viral Fitness Landscapes

Jumpei Ito, Adam Patrick Strange, Wei Liu…·Kei Sato

This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.

53 citationstop 1%

virusproteomics

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