Andrea J. O’Connor

This study develops hierarchical micro-nano biomaterials to enhance in vitro skeletal muscle maturation and neuromuscular junction formation by optimizing surface topography and ligand clustering.

This paper demonstrates that nanoclusters of integrin-, syndecan-, and dystroglycan-binding peptides on biomaterial surfaces enhance myoblast adhesion, proliferation, and differentiation in dystrophin-deficient cells.

This paper presents a method to create vascularized tissue constructs through angiogenesis from tissue-engineered vascular grafts, enabling implantable tissues to integrate with host circulation.