Gordon Stuart Lynch

This study develops hierarchical micro-nano biomaterials to enhance in vitro skeletal muscle maturation and neuromuscular junction formation by optimizing surface topography and ligand clustering.

This paper demonstrates that nanoclusters of integrin-, syndecan-, and dystroglycan-binding peptides on biomaterial surfaces enhance myoblast adhesion, proliferation, and differentiation in dystrophin-deficient cells.

This study identifies mitochondrial fusion and beta-oxidation as key drivers of muscle wasting in a Drosophila cancer cachexia model and shows interventions can mitigate muscle loss.

The paper develops FLT-seq and FLAMES to characterize full-length isoforms in single cells of human and mouse, identifying thousands of unannotated isoforms and linking them to functional modules and drug resistance mutations.