Mark L. Siegal

The paper identifies epistatic QTLs in budding yeast using a modified bulk segregant analysis approach that fixes one chromosome to detect genetic interactions.

The paper shows that in yeast lacking MutSβ function, mutations in simple sequence repeats are mostly deletions and occur at different rates depending on repeat length.

The paper introduces PIE, a software tool for automatically tracking microbial colony growth in low-resolution images, enabling large-scale analysis of growth and fluorescence properties.

The paper shows that feed-forward loops and diamond motifs evolve as signal filters, with dynamics rather than topology being key under intrinsic noise.

The paper introduces a family-based method to identify variance-controlling loci (vQTLs) that influence phenotypic variation, showing improved performance over existing methods in the presence of confounding.