Jakob Michaëlsson

The paper uses single-cell proteomics and transcriptomics to reveal cell-type-specific functional coordination in PBMCs, showing protein covariation that reflects protein-protein interactions and pathway rewiring.

mt-SCITE reconstructs cell lineages from mitochondrial mutations, outperforming existing methods and revealing subclonal relationships in CD8+ T cells post-vaccination.

This study examines fetal innate lymphoid cells (ILCs) across human tissues, revealing distinct distribution, developmental kinetics, and gene expression profiles, with a novel ILC progenitor identified in the fetal intestine.

The paper identifies heritable transcriptional diversity within cell types by studying clonal human lymphocytes and mouse brain cells, showing clone-specific chromatin accessibility leads to distinct gene expression.

This study uses long-read sequencing to analyze the genomic architecture of single human cells, revealing high-resolution genetic variation and structural variants.

The paper creates a comprehensive topographic atlas of early human lung development, identifying cell states, trajectories, and interactions to understand cell heterogeneity origins.

Conbase identifies clonal somatic mutations in single cells using read phasing, validated on simulated data and human samples.