Alexandra B. Firsova

A repair-associated bronchial epithelial differentiation trajectory through KRT14+ basal and hillock-like cells drives airway inflammation and remodelling in childhood-onset asthma

The paper identifies a novel asthma-associated epithelial differentiation trajectory involving KRT14+ basal cells and hillock-like cells that contributes to airway inflammation and remodelling in childhood-onset asthma.

Probe set selection for targeted spatial transcriptomics

Spapros selects optimal probe sets for targeted spatial transcriptomics to improve cell type identification and spatial variation detection across multiple datasets.

Spatially resolved transcriptomic profiling of degraded and challenging fresh frozen samples

The paper introduces RRST, a spatial transcriptomics workflow that improves mRNA recovery from low-quality fresh frozen samples, demonstrating its effectiveness across multiple tissue types.

Developmental origins of cell heterogeneity in the human lung

The paper creates a comprehensive topographic atlas of early human lung development, identifying cell states, trajectories, and interactions to understand cell heterogeneity origins.

SCRINSHOT, a spatial method for single-cell resolution mapping of cell states in tissue sections

SCRINSHOT maps cell states in tissue sections at single-cell resolution, showing high correlation with scRNA-Seq data and enabling detailed spatial analysis of cell types.