NeurosciencebioRxivPreprint
Brain insulin signaling restores deficits in striatal dopamine release in overweight male mice with preexisting low D2-receptor expression
Miriam E. Bocarsly, Jacqueline B. Mehr, Evan S. Swanson…·Veronica A. Alvarez
This study shows that low striatal D2 receptor density in male mice predisposes to obesity-like traits through early dopaminergic dysfunction, which is later compensated by brain insulin hypersensitivity.
DOI 10.1101/2025.10.28.685173