Miriam E. Bocarsly

Semaglutide Increases Striatal Leptin Sensitivity, Impacting Dopaminergic Response to Cocaine

This study shows chronic semaglutide treatment reduces cocaine-induced dopaminergic reward by enhancing striatal leptin sensitivity, with effects dependent on metabolic hormones.

Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors

This study investigates how DLS astrocytes contribute to EtOH-induced stimulation and drinking behavior through calcium signaling and cholinergic interactions in mice.

D2 autoreceptors gate vulnerability to cocaine use disorder

This study investigates how D2 autoreceptors influence vulnerability to cocaine use disorder by using cell-type-specific genetic manipulations in mice.

Susceptibility of Glucose Regulation to Social Isolation

This study shows that social isolation causes fasting hyperglycemia in male mice, which is mediated by testicular hormones and glucoregulatory brain neurons, but not in females.

Brain insulin signaling restores deficits in striatal dopamine release in overweight male mice with preexisting low D2-receptor expression

This study shows that low striatal D2 receptor density in male mice predisposes to obesity-like traits through early dopaminergic dysfunction, which is later compensated by brain insulin hypersensitivity.

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice

The paper generates mouse models with human mutations in TD genes, showing sensorimotor and reward learning phenotypes, dopamine changes, and sex-specific effects.