Ryan Kendrick Flannigan

This paper introduces a cuffed guide RNA (cgRNA) that enables miRNA activity-dependent genome editing in human and mouse cells.

TKSM simulates transcriptomic long-read sequencing data by modularly combining steps, enabling customizable and scalable benchmarking of sequencing tools.

scTagger matches cellular barcodes from long- and short-reads in single-cell RNA-seq experiments, showing improved accuracy and speed over existing methods.

The paper investigates YBX2 dysregulation in human testis samples and finds reduced YBX2 and PRM1/2 mRNA in maturation arrest, linked to COMP levels and impaired spermatogenesis.