Yike Xie

This study maps spatial and functional states of human pancreatic cells in health and disease using combined single-cell and spatial transcriptomics with calcium imaging.

The paper uses cfDNA/cfRNA sequencing to identify molecular correlates of bNAb development in HIV patients, finding an MHC class I activation signature and microbial changes associated with bNAb production.

This paper introduces Ukiyo-e-Seq, a method to simultaneously capture optical and transcriptomic data from individual eukaryotic plankton, enabling the integration of morphology and genetics for improved classification and functional analysis.

HyperSeq integrates hyperspectral imaging and transcriptomics on the same cell to link optical spectra with molecular states in MCF-7 breast cancer cells.

The paper uses single-cell transcriptomics and in-situ imaging to study lung mesenchymal cell diversity during development and hyperoxia, finding delayed diversity and emergence of Acta1+ cells under hyperoxic conditions.