Xibing Che

Postnatal Abrogation of VEGFR2 Blocks Terminal Cap2 Differentiation by Preventing the Developmental Progression from a Capillary Intermediate Cell State

This study shows that postnatal VEGFR2 abrogation blocks Cap2 differentiation by preventing the transition from Cap1 to CapINT, impairing alveolarization and activating fibroblasts.

Lung mesenchymal cell diversity rapidly increases at birth and is profoundly altered by hyperoxia

The paper uses single-cell transcriptomics and in-situ imaging to study lung mesenchymal cell diversity during development and hyperoxia, finding delayed diversity and emergence of Acta1+ cells under hyperoxic conditions.

Developmental diversity and unique sensitivity to injury of lung endothelial subtypes during a period of rapid postnatal growth

The paper profiles the transcriptional development and injury sensitivity of lung endothelial subtypes during postnatal growth, revealing distinct transcriptomic changes and differential responses to hyperoxia.

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung revealed at single cell resolution

This study uses single-cell transcriptomics to reveal diverse immune cell roles in the developing mouse lung, showing dynamic changes in macrophage subtypes and their functions during lung development.