Arne Claeys

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

The paper uses spatial transcriptomics to analyze neuroblastoma microenvironments, identifying novel paracrine interactions between cancer cells and surrounding cells.

The paper benchmarks 13 HLA genotyping tools on three datasets to identify the most accurate methods and provides consensus predictions for TCGA samples.

The paper uses post-mortem tissues to study mutational clonality in healthy tissues, finding smoking-induced clonal changes in oral epithelia and confirming NOTCH1/2-, TP53-, and FAT1-driven clones.