Joachim T. Siaw

This study identifies RUVBL1 and RUVBL2 as druggable regulators of MYCN in neuroblastoma, showing their inhibition reduces MYC signaling and induces cell cycle arrest and apoptosis.

This study repurposes statins and phenothiazines to treat chemoresistant neuroblastoma, showing synergistic effects and improved survival in preclinical models.

The paper uses spatial transcriptomics to analyze neuroblastoma microenvironments, identifying novel paracrine interactions between cancer cells and surrounding cells.

The paper uses post-mortem tissues to study mutational clonality in healthy tissues, finding smoking-induced clonal changes in oral epithelia and confirming NOTCH1/2-, TP53-, and FAT1-driven clones.