Le Thanh Tu Nguyen

The paper identifies new phosphorothioate DNA modification systems in the human gut microbiome using genomic and mass spectrometric analysis.

The paper investigates how industrialization affects microbial and physiological traits in the human gut across diverse populations, finding homogenized microbiomes, reduced diversity, and impaired disease prediction accuracy in less industrialized groups.

The paper shows that individuals vary in their gut microbiota's ability to ferment dietary fibers, leading to different SCFA production, and suggests personalized fiber supplementation as a therapeutic strategy.