Benzothiazole Derivatives as Dual Modulators of PGE2 and GABAergic Signaling in Skeletal Muscle
Marian N. Aziz, Kamal R. Awad, Jian Huang, Zhiying Wang, Venu Gopal Varanasi, Marco A. P. Brotto, Carl J. Lovely
This study identifies benzothiazole derivatives that modulate PGE2 and GABAergic signaling in skeletal muscle cells, with one compound downregulating Gabrg2, suggesting links between muscle signaling and neuropsychiatric disorders.
bioRxiv · Jun 3, 2026 · PreprintPharmacology & Toxicology