Jian Huang

Xenograft supervision and joint methylation-fragment-end encoding define a reusable molecular scoring layer for cell-free tumor DNA

ctDNA-BERT scores individual bisulfite reads for cell-free DNA methylation analysis, achieving high accuracy in cancer staging without cohort-specific retraining.

Hidden genetic diversity in 320 nearly-complete East Asian genome assemblies

The paper presents 320 nearly-complete East Asian genome assemblies, revealing new genetic diversity and structural variations not present in existing global pangenomes.

Benzothiazole Derivatives as Dual Modulators of PGE2 and GABAergic Signaling in Skeletal Muscle

This study identifies benzothiazole derivatives that modulate PGE2 and GABAergic signaling in skeletal muscle cells, with one compound downregulating Gabrg2, suggesting links between muscle signaling and neuropsychiatric disorders.

Integrated Metagenomics and Metabolomics Studies Reveal Core Bacterial Guild Regulating Carbohydrate Metabolism in Pediatric MASLD

This study integrates metagenomics and metabolomics to identify core bacterial species regulating carbohydrate metabolism in pediatric MASLD, highlighting their role in metabolic disruption.

Genetic liability to metabolic dysfunction modelled in early adulthood predicts cardiometabolic risk across the life course in Asian populations

This paper develops a polygenic score for metabolic syndrome in early adulthood and shows it predicts cardiometabolic risk across the life course in Asian populations.

SR2P: an efficient stacking method to predict protein abundance from gene expression in spatial transcriptomics data

SR2P predicts protein abundance from RNA expression in spatial transcriptomics data, improving immune cell identification in tumors.

Fast Loading and Transformation of Large-Volume Bioimaging Data Consistently Approaching the I/O Peak Speed

The paper introduces a bioimaging data processing pipeline that improves data transformation efficiency and accelerates downstream tasks by optimizing I/O throughput and reducing memory overhead.