Mariia Minaeva

This study modulates gene dosage using CRISPR and examines nonlinear transcriptional responses to dosage changes in three master transcription factors, revealing non-monotonic effects and links to disease genes.

The paper develops a method to define cell-specific transcription factor regulons and demonstrates their utility in analyzing transcriptional dysregulation in cancer.

Pretrained on 57 million dissociated and 53 million spatial human and mouse cells, a 49.3M-parameter transformer predicts niche, region, neighborhood composition and density, and carries spatial labels onto scRNA-seq.

This study catalogs sQTLs using PSI scores and uses AlphaFold2 to predict protein structure changes linked to GWAS traits.