Robert Tycko

The paper characterizes three polymorphic structures of rapidly twisting Aβ40 fibrils using cryo-EM, revealing differences in twist handedness, symmetry, and conformation despite similar cross-over distances.

This paper investigates how nanopore confinement affects the conformational and self-assembly properties of an FG-repeat peptide using NMR and electron microscopy.

The paper investigates whether local conformational distributions of FUS-LC differ between homogeneous and phase-separated states using ssNMR and finds they are nearly identical.