Myungwoon Lee

This study uses experimental and molecular dynamics methods to show that Aβ40 and Aβ42 have distinct co-assembly pathways with lipids, with lipid effects varying by isoform and lipid composition.

This study shows that Aβ42 monomers and preformed fibrils differentially affect α-synuclein fibril formation, structure, and neuronal toxicity.

This study develops a vascularized brain model to investigate how vascular dysfunction contributes to Parkinson's disease pathology by inducing α-synuclein aggregation in neurons.

This study shows that age-related membrane changes affect α-synuclein fibril structure and pathogenicity, linking membrane dynamics to neurodegeneration.

This paper develops an organ-on-a-chip model of dopaminergic neurons and capillaries to study vascular changes in Parkinson's Disease.

The paper investigates whether local conformational distributions of FUS-LC differ between homogeneous and phase-separated states using ssNMR and finds they are nearly identical.

This study shows that SARS-CoV-2 N-protein uses two distinct RNA motifs, both requiring dsRNA, to drive phase separation at specific temperatures, enabling multiple viral functions.