Author

Edgar E. Nollet

University of CopenhagenORCID 0000-0001-7047-2538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Alexander HirschiD· 1 shared Claudine W.B. RuijmbeekiD· 1 shared Diederik W.D. KusteriD· 1 shared Federico FerraroiD· 1 shared Henk S. SchipperiD· 1 shared Herma C. van der LindeiD· 1 shared Inez DuursmaiD· 1 shared Jan H. von der ThüseniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Alexander HirschORCID

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2 papers

Recent·Most cited

PhysiologyJournal of Molecular and Cellular Cardiology PlusPeer-reviewedMar 1, 2026

Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy

Inez Duursma, Linda Renata Micali, Edgar E. Nollet…·Diederik W.D. Kuster

This study shows that microtubule detyrosination in HCM causes nuclear shape changes and YAP1 signaling, which can be reversed by inhibiting detyrosination.

3 citationstop 2%

humanmouse

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Genetic & Genomic MedicinemedRxivPreprintJan 11, 2025

Bi-allelic variants in the aminopeptidase XPNPEP3 cause mitochondrial disease with pediatric cardiomyopathy

Claudine W.B. Ruijmbeek, Sjoerd Ruizenaar, Herma C. van der Linde…·Judith M. A. Verhagen

This study identifies bi-allelic XPNPEP3 variants causing mitochondrial disease with pediatric cardiomyopathy, revealing impaired mitochondrial protein processing as the underlying mechanism.

1 citation

humanzebrafish

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