José María Frade

This study shows that neuronal expression of E2F4DN restores adult neurogenesis in 5xFAD mice by enhancing TrkB signaling in neural stem cells.

The paper shows that E2F4DN, a non-phosphorylatable mutant of E2F4, reduces neuronal death by upregulating Cited2, suggesting its neuroprotective role in Alzheimer's disease.

The paper shows that primary neurons can enter mitosis under oncogenic conditions, leading to cell death instead of division, and highlights axonal adaptations during this process.