Molecular BiologybioRxivPreprint
Single adeno-associated virus-based multiplexed CRISPR-Cas9 system to nullify core components of the mammalian molecular clock
Boil Kim, Jihoon Kim, Minjeong Chun…·Han Kyoung Choe
The paper develops a CRISPR-Cas9-based AAV system to knock out multiple circadian clock genes and demonstrates its effectiveness in disrupting molecular circadian rhythms in vivo.
DOI 10.1101/2020.07.02.184119