Author

Joshua H. Choe

Broad InstituteORCID 0000-0001-7094-3766Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Andrew J. AguirreiD· 2 shared Aparna PadhyeiD· 1 shared Bin Zou· 1 shared Brendan D. ParentiD· 1 shared Bryan K. S. YeungiD· 1 shared Clint A. StalneckeriD· 1 shared David H. PengiD· 1 shared Elizabeth Y. KimiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

Andrew J. AguirreORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2026

KRAS inhibition drives adaptive surfaceome remodeling and reveals ALPP/ALPPL2 as a targetable vulnerability in pancreatic cancer

Jonathan M. DeLiberty, Fan Yi Kong, Qijia Yu…·Joseph Douglas Mancias

This study identifies ALPP/ALPPL2 as a targetable vulnerability in pancreatic cancer by analyzing proteomic changes induced by KRAS inhibition and developing an antibody drug conjugate.

DOI 10.64898/2026.10.01.756025

humanproteomics

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Cancer BiologybioRxivPreprintSep 16, 2025

VEGFR2 blockade overcomes acquired KRAS G12D inhibitor resistance driven by PI3Kγ activation

Sung‐Hyun Hwang, Mingyun Bae, Ji‐Won Kim…·Keun‐Wook Lee

This paper identifies VEGFA-VEGFR2 signaling driven by PI3Kγ activation as a mechanism of acquired resistance to KRAS G12D inhibitors and shows that blocking this pathway restores drug sensitivity in resistant cancer models.

DOI 10.1101/2025.09.16.676456

humanscRNA-seq

𝕏 PostBluesky