KRASG12C Inhibition Remodels the Non-Small Cell Lung Cancer Surfaceome to Uncover Targetable Vulnerabilities
Aparna Padhye, Kalisa Kang, Fan Yi Kong, Nicole Sindoni, Qijia Yu, 柏岐 姜, Wen-Hsuan Chang, Oluwadara Coker, Eejung Kim, Julien Dilly, Myungsun Shin, Joao A. Paulo, Kathleen Sprouffske, Saskia M. Brachmann, Clint A. Stalnecker, , Joseph Douglas Mancias
This study shows that KRASG12C inhibitors alter the surface proteome of lung cancer cells, revealing FOLR1 as a new target when combined with an antibody drug conjugate.
bioRxiv · Oct 2, 2026 · PreprintCancer Biology