Zachary W. Dwyer

Transcript-specific determinants of pre-mRNA splicing revealed through in vivo kinetic analyses of the 1st and 2nd chemical steps

The paper measures in vivo rates of the first and second chemical steps of pre-mRNA splicing across the genome and identifies splice site sequences and ribosomal protein gene features as key determinants of splicing rates.

High Precision Detection of Rare Splice Isoforms Using Multiplexed Primer Extension Sequencing

The paper introduces a targeted RNA-sequencing method using complex primer pools to detect rare splice isoforms with high precision.